Monday, October 26, 2009
Decided on a Topic
I've finally decided (a day before I have to meet with my TA to discuss my progress) to research the treatment of type I diabetes using stem cells taken from the patient's own body and dedifferentiated. The details of this process, which involve the suppression of the patient's immune system to prevent rejection, will be the focus of my research paper. One problem that I think I'm going to run into, after gathering some sources, is that the experiments and results that I've found all contain small variations in method and execution. Some procedures use stem cells created from the patient's blood cells, others use skin cells or cells taken from bone marrow. The method of dedifferentiation also seems to be different between the experiments. The results are also measured in different ways. Levels of C-peptide, certain antibodies, and hemoglobin A(1C), or different combination of these indicators are all used to gauge the effectiveness of the treatment. I think I will have to think of some way to form a baseline or common measurement system to be able to compare these various sources. On the plus side, though, the dedifferentiation method in each experiment is constant: some kind of procedure named autologous nonmyeloablative hematopoietic stem cell transplantation (or HSCT for short), which, judging from the name, I'm sure will take many hours of staring for me to understand it enough to describe in the research paper.
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